Description

Sar-1-Ile-8-Angiotensin II Acetate is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, modified at positions 1 and 8 to enhance its stability and receptor-binding profile. This compound is a critical research tool for studying the renin-angiotensin system (RAS), cardiovascular physiology, and hypertension. It is essential for pharmaceutical R&D, academic research, and the development of diagnostic assays targeting angiotensin receptors.

Application

• Biomedical Research: Used as a reference standard and agonist in studies of the renin-angiotensin-aldosterone system (RAAS), vascular smooth muscle contraction, and blood pressure regulation.
• Pharmacology & Drug Discovery: Serves as a key ligand for screening and characterizing angiotensin II receptor type 1 (AT1) antagonists and for validating new therapeutic candidates for hypertension and heart failure.
• Diagnostic Development: Employed in the development and calibration of immunoassays (e.g., ELISA, RIA) to measure angiotensin II levels or receptor activity in biological samples.
• Cell Signaling Studies: Applied in vitro to investigate G-protein coupled receptor (GPCR) signaling pathways, intracellular calcium mobilization, and cellular hypertrophy.
• Biochemical Assays: Used in enzyme activity studies, such as those involving angiotensin-converting enzyme (ACE), to determine inhibitory potency of potential drugs.
• Academic & Educational Use: A standard reagent in university laboratories for teaching advanced concepts in endocrinology, peptide chemistry, and cardiovascular pharmacology.

Basic Information

Product Name	Sar-1-Ile-8-Angiotensin II Acetate
CAS No.	67724-27-0
Molecular Formula	C49H69N13O11 • (C2H4O2)x
Molecular Weight	1031.2 g/mol (free base)
Synonyms	[Sar1,Ile8]-Angiotensin II; Sarile; Sar-Ile-Angiotensin II; Sarcosin1,Isoleucine8-Angiotensin II; Angiotensin II Sar1 Ile8; ATII Analog; H-Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH Acetate
EINECS	Contact for details

Quality Control

Every batch of Sar-1-Ile-8-Angiotensin II Acetate is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. A detailed Certificate of Analysis (COA), including results from HPLC, MS, and amino acid analysis, is supplied with each shipment to guarantee it meets your specific research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	1.0 - 10.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.