Description

(+/-)-1-Aminocyclopentane-trans-1,3-Dicarboxylic Acid CAS NO 67684-64-4 is a high-purity, non-proteinogenic amino acid derivative that serves as a critical chiral building block and a potent, selective group II metabotropic glutamate receptor (mGluR) antagonist. Its unique cyclopentane backbone and dicarboxylic acid functionality make it an invaluable intermediate for advanced pharmaceutical research and development. This compound is essential for medicinal chemists and researchers in neuroscience, pharmacology, and organic synthesis who require high-quality, well-characterized chemical tools.

Application

• Neuroscience Research: As a selective antagonist for group II metabotropic glutamate receptors (mGluR2/3), it is a key pharmacological tool for studying synaptic transmission, neuroplasticity, and neurological disorders.
• Pharmaceutical Intermediate: Serves as a sophisticated chiral building block in the synthesis of novel central nervous system (CNS) active drug candidates and other bioactive molecules.
• Biochemical Assay Development: Used in high-throughput screening (HTS) and in vitro assays to identify and characterize new modulators of glutamate receptor pathways.
• Medicinal Chemistry: Provides a constrained scaffold for structure-activity relationship (SAR) studies aimed at developing new therapeutics for conditions like anxiety, depression, and schizophrenia.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for fundamental studies in neurochemistry and receptor pharmacology.

Basic Information

Product Name	(+/-)-1-Aminocyclopentane-trans-1,3-Dicarboxylic Acid
CAS No.	67684-64-4
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	trans-ACPD; (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic Acid; (1α,3β)-1-Aminocyclopentane-1,3-dicarboxylic Acid; ACPD; trans-1-Aminocyclopentane-1,3-dicarboxylic Acid; Group II mGluR Antagonist; (RS)-1-Aminocyclopentane-trans-1,3-dicarboxylic Acid
EINECS	Contact for details

Quality Control

Our (+/-)-1-Aminocyclopentane-trans-1,3-Dicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with your specifications. Our commitment to cGMP principles and rigorous quality assurance protocols guarantees a reliable supply of this high-value research chemical.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require desiccant. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.