Description

L-Tolperisone CAS NO 67499-66-5 is a centrally acting muscle relaxant belonging to the class of tolperisone derivatives. This compound is of significant commercial interest for its role as a key active pharmaceutical ingredient (API) in the formulation of medications designed to alleviate muscle spasms and associated pain. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of neurological and musculoskeletal therapeutics.

Application

• Primary Active Pharmaceutical Ingredient (API) in muscle relaxant formulations.
• Research and development of new central nervous system (CNS) acting drugs.
• Manufacturing of generic pharmaceutical products targeting spasticity and muscle pain.
• Reference standard for analytical testing and quality control in pharmaceutical labs.
• Preclinical studies investigating mechanisms of muscle relaxation.
• Potential intermediate in the synthesis of novel tolperisone analogs.

Basic Information

Product Name	L-Tolperisone
CAS No.	67499-66-5
Molecular Formula	C₁₆H₂₃NO
Molecular Weight	245.36 g/mol
Synonyms	2,4'-Dimethyl-3-piperidinopropiophenone; (RS)-2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone; Mydocalm; Mydetone; Eperisone Hydrochloride (related salt); Tolperisone Hydrochloride (racemic mixture); Muscalm; CAS 728-88-1 (often for hydrochloride salt)
EINECS	Contact for details

Quality Control

Our L-Tolperisone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications for identity, purity, and impurity profiles. We support compliance with cGMP and relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.