Description

(-)-Tolperisone Hydrochloride CAS NO 67499-63-2 is the specific levorotatory enantiomer of the centrally acting muscle relaxant Tolperisone. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of advanced pharmaceutical formulations. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of enantiomerically pure muscle relaxant medications and neurological research.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of enantiomerically pure muscle relaxant drugs.
• Neurological Research: Used as a reference standard and investigational compound in studies of spasticity and muscle tone regulation.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Formulation Development: Key component in the R&D of new dosage forms, including tablets, capsules, and controlled-release systems.
• Comparative Bioavailability Studies: Employed in studies comparing the pharmacokinetics of different enantiomeric forms.

Basic Information

Product Name	(-)-Tolperisone Hydrochloride
CAS No.	67499-63-2
Molecular Formula	C16H23NO • HCl
Molecular Weight	281.82 g/mol
Synonyms	(-)-Tolperisone HCl; (2-Methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one) Hydrochloride; Levotolperisone Hydrochloride; Mydocalm (enantiomer); Mydetone; Eperisone Hydrochloride isomer; 2-Methyl-3-(1-piperidyl)-1-p-tolylpropan-1-one Hydrochloride (S-form)
EINECS	Contact for details

Quality Control

Our (-)-Tolperisone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.