Description

Abz-Gly-4-Nitro-Phe-Pro-Oh is a specialized, fluorogenic peptide substrate designed for sensitive enzymatic assays. This compound is critical for researchers and manufacturers requiring precise, high-throughput detection of protease activity, particularly for enzymes like dipeptidyl peptidase IV (DPP-IV). It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic industries for drug discovery, biochemical research, and assay development.

Application

• Protease Activity Assays: A key fluorogenic substrate for the continuous monitoring of DPP-IV and related protease activities in kinetic studies.
• High-Throughput Screening (HTS): Enables rapid screening of enzyme inhibitors and activators in drug discovery pipelines for metabolic and inflammatory diseases.
• Biochemical Research: Used in mechanistic studies to understand protease specificity, kinetics, and function in various biological pathways.
• Diagnostic Kit Development: Serves as a core component in the formulation of diagnostic kits for measuring enzyme levels in clinical and research samples.
• Quality Control in Biologics: Employed in the QC testing of therapeutic proteins to monitor for the presence of specific protease contaminants.

Basic Information

Product Name	Abz-Gly-4-Nitro-Phe-Pro-Oh
CAS No.	67482-93-3
Molecular Formula	C27H29N5O8
Molecular Weight	551.55 g/mol
Synonyms	Abz-Gly-pNO2-Phe-Pro-OH; 2-Aminobenzoyl-Glycyl-4-nitrophenylalanyl-proline; DPP-IV Substrate (Abz-Gly-pNO2-Phe-Pro-OH); Fluorogenic DPP-IV Substrate; H-Gly-pNO2-Phe-Pro-OH (Abz-labeled); 4-Nitro-Phe-Pro Dipeptide Derivative; Peptide Substrate 67482-93-3
EINECS	Contact for details

Quality Control

Our Abz-Gly-4-Nitro-Phe-Pro-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, essential for reliable assay performance. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and performance. For long-term storage, consider storing at -20°C under desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.