Description

n-Me-cis-Hydroxyproline CAS NO 67463-44-9 is a specialized, non-proteinogenic amino acid derivative, specifically an N-methylated analog of cis-4-hydroxyproline. This compound is a critical chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications such as peptide synthesis, drug discovery, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting collagen-related disorders or requiring specific conformational control.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce N-methylated proline analogs, which can enhance metabolic stability and alter the conformational properties of therapeutic peptides.
• Biochemical Research: Serves as a standard or reference compound in studies of collagen metabolism, enzyme inhibition, and amino acid transport mechanisms.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of N-methylation and hydroxylation on the potency and selectivity of lead compounds.
• Fine Chemical Synthesis: Acts as a versatile building block for the preparation of more complex, optically active molecules in asymmetric synthesis.

Basic Information

Product Name	n-Me-cis-Hydroxyproline
CAS No.	67463-44-9
Molecular Formula	C₆H₁₁NO₃
Molecular Weight	145.16 g/mol
Synonyms	N-Methyl-cis-4-hydroxyproline; (2S,4R)-1-Methyl-4-hydroxypyrrolidine-2-carboxylic acid; cis-4-Hydroxy-N-methylproline; 1-Methyl-4-hydroxy-L-proline (cis); L-cis-4-Hydroxy-N-methylproline; N-Methyl-4-hydroxy-L-proline (cis); 4-Hydroxy-N-methylproline (cis)
EINECS	Contact for details

Quality Control

Our n-Me-cis-Hydroxyproline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and specific tests is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which could affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (cis isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.