Description

Warfarin Sodium Clatharate is a stabilized, crystalline form of the widely used anticoagulant agent, warfarin sodium. This specific clathrate formulation enhances the chemical stability and handling properties of the active pharmaceutical ingredient, which is critical for ensuring consistent potency and shelf life in final drug products. It is an essential raw material primarily for the pharmaceutical industry in the manufacturing of anticoagulant medications for the prevention and treatment of thromboembolic disorders.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key active component in the manufacture of oral anticoagulant tablets and injectable formulations.
• Anticoagulant Therapy: Used in medications for the prevention and treatment of deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke in patients with atrial fibrillation.
• Prevention of Systemic Embolism: Incorporated into drugs prescribed for patients with prosthetic heart valves or other conditions posing a high risk of clot formation.
• Reference Standard: Serves as a high-purity chemical reference standard in analytical laboratories for quality control and research purposes.
• Veterinary Medicine: Employed in the production of anticoagulant rodenticides and in specific veterinary therapeutic applications.
• Biomedical Research: Utilized in biochemical and pharmacological research to study blood coagulation pathways and vitamin K antagonism.

Basic Information

Product Name	Warfarin Sodium Clatharate
CAS No.	67430-45-9
Molecular Formula	C19H15NaO4 • (Clathrate)
Molecular Weight	330.31 g/mol (for Warfarin Sodium)
Synonyms	Warfarin Sodium Clathrate; 3-(α-Acetonylbenzyl)-4-hydroxycoumarin Sodium Salt Clathrate; Coumadin Sodium Clathrate; Marevan Sodium Clathrate; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one Sodium Salt Clathrate; Sodium Warfarin Clathrate; Warfarin Sod. Clath.
EINECS	Contact for details

Quality Control

Our Warfarin Sodium Clatharate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines and current Good Manufacturing Practices (cGMP). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed-upon specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.