Description

Z-Gly-Pro-βna CAS NO 67336-99-6 is a protected dipeptide derivative, specifically N-(Benzyloxycarbonyl)glycyl-L-proline benzylamide, widely utilized as a key synthetic intermediate in peptide chemistry. This compound is valued for its role in constructing more complex peptide sequences while providing orthogonal protection for the N-terminus. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, protease inhibitors, and biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates.
• Protease Inhibitor Research: Used in the design and study of inhibitors targeting proline-specific enzymes due to its proline residue.
• Biochemical Tool Development: Employed in the preparation of substrates for enzyme activity assays and mechanistic studies.
• Academic & R&D: A standard reagent in university and contract research organization (CRO) laboratories for peptide methodology development.
• Custom Peptide Synthesis: Provides a protected fragment for the efficient production of custom peptides for biological screening.

Basic Information

Product Name	Z-Gly-Pro-βna
CAS No.	67336-99-6
Molecular Formula	C22H25N3O4
Molecular Weight	395.45 g/mol
Synonyms	N-(Benzyloxycarbonyl)glycyl-L-proline benzylamide; Z-Gly-Pro-NH-Bzl; Cbz-Gly-Pro-Benzylamide; N-Carbobenzoxy-glycyl-proline benzylamide; Benzyl N-[(benzyloxy)carbonyl]glycyl-L-prolinate; Z-Gly-Pro-Bzl; Nα-Cbz-Glycyl-L-proline Benzyl Ester; (S)-Benzyl 1-((((benzyloxy)carbonyl)glycyl)prolinate
EINECS	Contact for details

Quality Control

Our Z-Gly-Pro-βna is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.