Description

Cholylglycyltyrosine CAS NO 67319-56-6 is a synthetic peptide derivative of cholic acid, a primary bile acid, conjugated with the dipeptide glycyl-tyrosine. This compound is of significant value in biochemical and pharmaceutical research, serving as a key reference standard and synthetic intermediate. It is primarily needed by research institutions and pharmaceutical developers working on bile acid metabolism, receptor studies, and the development of novel diagnostic agents or therapeutic conjugates.

Application

• Biochemical Research Standard: Used as a high-purity reference material for calibrating analytical instruments like HPLC and mass spectrometry in bile acid studies.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex peptide-bile acid conjugates for drug delivery and targeting.
• Metabolic Pathway Studies: Employed in in vitro and cell-based assays to investigate the role of conjugated bile acids in metabolic processes and signaling.
• Enzyme Substrate/Analyte: Acts as a specific substrate for studying the activity of enzymes like bile salt hydrolases or for use in diagnostic kit development.
• Receptor Binding Assays: Utilized in research focused on the Farnesoid X Receptor (FXR) and other nuclear receptors that bind bile acid derivatives.

Basic Information

Product Name	Cholylglycyltyrosine
CAS No.	67319-56-6
Molecular Formula	C36H52N2O8
Molecular Weight	640.81 g/mol
Synonyms	Cholyl-Gly-Tyr; N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycyl-L-tyrosine; Glycocholylyrosine; Taurocholylyrosine analog; Cholic acid-glycyl-tyrosine conjugate; L-Tyrosine, N-[2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxo-24-cholan-24-yl]amino]acetyl]-; Bile acid-peptide conjugate
EINECS	Contact for details

Quality Control

Our Cholylglycyltyrosine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.