Description

2-(6-Bromo-4-Oxo-3,4-Dihydroquinazolin-3-Yl)Acetic Acid CAS NO 67305-46-8 is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition and other therapeutic pathways. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of next-generation oncology and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic candidates.
• Organic Synthesis Building Block: Utilized for constructing complex heterocyclic frameworks due to its reactive bromo and carboxylic acid functional groups.
• Biochemical Research: Employed in the development of chemical probes and assay tools for studying enzyme function and cellular signaling pathways.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.

Basic Information

Product Name	2-(6-Bromo-4-Oxo-3,4-Dihydroquinazolin-3-Yl)Acetic Acid
CAS No.	67305-46-8
Molecular Formula	C₁₀H₇BrN₂O₃
Molecular Weight	283.08 g/mol
Synonyms	2-(6-Bromo-4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid; 3-Carboxymethyl-6-bromo-4(3H)-quinazolinone; 6-Bromo-3-(carboxymethyl)-4(3H)-quinazolinone; 6-Bromo-3-carboxymethyl-4(3H)-quinazolinone; 2-(6-Bromo-4-oxoquinazolin-3(4H)-yl)acetic acid; (6-Bromo-4-oxo-3,4-dihydroquinazolin-3-yl)acetic acid; CAS 67305-46-8
EINECS	Contact for details

Quality Control

Our production of 2-(6-Bromo-4-Oxo-3,4-Dihydroquinazolin-3-Yl)Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical research and manufacturing applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically verified by HPLC, NMR, and mass spectrometry. We support development projects requiring material produced under GMP-like conditions and can provide stability data upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.