Description

2-(Difluoromethyl)Aniline is a versatile fluorinated aromatic amine building block, essential for introducing the difluoromethyl group into complex molecular architectures. Its unique structure offers significant advantages in modulating the lipophilicity, metabolic stability, and bioavailability of target compounds. This high-purity intermediate is critically needed by pharmaceutical, agrochemical, and advanced material research and development teams for synthesizing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoromethyl group enhances biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated compounds used in electronic displays and organic light-emitting diodes.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific chemical resistance or surface properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a precursor for heterocyclic compounds in academic and industrial research.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated colorants with improved fastness properties.

Basic Information

Product Name	2-(Difluoromethyl)Aniline
CAS No.	67272-07-5
Molecular Formula	C7H7F2N
Molecular Weight	143.13 g/mol
Synonyms	2-(Difluoromethyl)benzenamine; 2-Aminobenzylidene Difluoride; o-(Difluoromethyl)aniline; Benzenamine, 2-(difluoromethyl)-; 2-(Difluoromethyl)phenylamine; 2-Difluoromethylphenylamine; 67272-07-5; α,α-Difluoro-o-toluidine
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.