Description

Boc-Met-Leu-Phe-Oh is a protected tripeptide derivative, a crucial building block in solid-phase peptide synthesis (SPPS). Its value lies in the strategic protection of the N-terminal amino group with a tert-butyloxycarbonyl (Boc) group, allowing for selective deprotection and controlled chain elongation. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of complex peptide drug candidates and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in academic and industrial R&D for studying peptide structure-activity relationships (SAR) and protein-protein interactions.
• Peptide Library Synthesis: A critical component in combinatorial chemistry for generating diverse peptide libraries used in high-throughput screening.
• Custom Peptide Synthesis: Employed by CROs and CDMOs for the custom production of specific peptide sequences for clients.
• Protease Substrate Analogues: Can be utilized to develop substrates or inhibitors for enzymes like chymotrypsin or related proteases.
• Material Science: Potential use in the development of bio-conjugates, peptide-polymer hybrids, and advanced biomaterials.

Basic Information

Product Name	Boc-Met-Leu-Phe-Oh
CAS No.	67247-12-5
Molecular Formula	C26H41N3O6S
Molecular Weight	523.69 g/mol
Synonyms	Boc-Met-Leu-Phe-OH; Boc-MLF-OH; N-(tert-Butoxycarbonyl)-L-methionyl-L-leucyl-L-phenylalanine; tert-Butyloxycarbonyl-Methionyl-Leucyl-Phenylalanine; N-Boc-L-Methionyl-L-Leucyl-L-Phenylalanine; Boc-L-Met-L-Leu-L-Phe-OH; (2S)-2-[[(2S)-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid; Boc-Met-Leu-Phe
EINECS	Contact for details

Quality Control

Our Boc-Met-Leu-Phe-Oh is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via mass spectrometry (MS) and infrared (IR) spectroscopy. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the COA. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use and allowed to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.