Description

Acth (4-11) CAS NO 67224-41-3 is a synthetic peptide fragment derived from the adrenocorticotropic hormone (ACTH) sequence, representing amino acids 4 through 11. This specific fragment is of significant interest in biochemical and pharmaceutical research for studying melanocortin receptor activity and related physiological pathways. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in peptide synthesis, neuroendocrine research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of melanocortin receptors (MC1R, MC3R, MC4R, MC5R).
• Pharmaceutical Development: Serves as a key intermediate or lead compound in the discovery of drugs targeting metabolic, inflammatory, and neurological disorders.
• Neuroscience Studies: Applied in research investigating the role of ACTH fragments in stress response, behavior, and learning.
• Peptide Synthesis: Acts as a building block for the synthesis of longer, modified ACTH analogs with enhanced stability or specificity.
• In-vitro Diagnostics: May be employed in the development of immunoassays and other diagnostic tools for endocrine function.

Basic Information

Item	Details
Product Name	Acth (4-11)
CAS No.	67224-41-3
Molecular Formula	C46H68N12O12S
Molecular Weight	965.2 g/mol
Synonyms	ACTH (4-11); Adrenocorticotropic Hormone (4-11); H-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-OH; Melanotropin (4-11); α-MSH (4-11); [Met(O2)]-ACTH (4-11) (oxidized form); ACTH Fragment 4-11
EINECS	Contact for details

Quality Control

Our Acth (4-11) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide Certificates of Analysis (COA) with detailed specifications for every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.