Description

Pglu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Hyp-Gly-Nh2 is a synthetic decapeptide amide, a structural analog of gonadotropin-releasing hormone (GnRH). This compound is of significant interest for its role in modulating the hypothalamic-pituitary-gonadal axis and serves as a critical reference standard and research tool. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on endocrinology, reproductive health, and peptide-based therapeutic development.

Application

• Pharmaceutical Reference Standard: Used for the calibration, validation, and quality control of analytical methods (HPLC, MS) in drug development and manufacturing.
• Biochemical Research: Serves as a key reagent in studies investigating the structure-activity relationships (SAR) of GnRH and its receptor interactions.
• Endocrinology Studies: Applied in *in vitro* and *in vivo* research to understand the regulation of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
• Peptide Synthesis Intermediate: Acts as a building block or precursor in the custom synthesis of more complex peptide analogs for therapeutic screening.
• Diagnostic Development: Potential use in the development of immunoassays and diagnostic kits targeting the GnRH pathway.

Basic Information

Product Name	Pglu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Hyp-Gly-Nh2
CAS No.	67019-13-0
Molecular Formula	C₅₆H₇₈N₁₈O₁₄
Molecular Weight	1187.34 g/mol
Synonyms	GnRH (1-10) amide; Gonadorelin (1-10) amide; Luliberin (1-10) amide; Pyroglutamyl-Histidyl-Tryptophyl-Seryl-Tyrosyl-Glycyl-Leucyl-Arginyl-Hydroxyprolyl-Glycinamide; pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Hyp-Gly-NH₂; LH-RH (1-10) amide; Follicle-Stimulating Hormone–Releasing Factor (1-10) amide; Decapeptide Amide GnRH Analog
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality management systems. Each batch of Pglu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Hyp-Gly-Nh2 undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide Certificates of Analysis (COA) with detailed chromatographic data and specifications. Production can be aligned with cGMP guidelines for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider lyophilized powder under inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	Within ±10% of theoretical values

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.