Description

Glycochenodeoxycholic Acid 3-Sulfate Disodium Salt is a high-purity, sulfated bile acid derivative, a critical biochemical reagent for advanced research and development. Its primary value lies in its role as a key reference standard and metabolic intermediate for studying bile acid conjugation, sulfation pathways, and hepatobiliary function. This compound is essential for pharmaceutical R&D teams, clinical diagnostic manufacturers, and academic researchers focused on liver metabolism, cholestatic diseases, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and validation of analytical methods in drug development, particularly for liver-targeted therapies.
• Metabolic Pathway Research: A crucial substrate for investigating the enzymatic processes of bile acid sulfation and its impact on detoxification and elimination in hepatobiliary systems.
• Diagnostic Assay Development: Serves as a calibrator and control in the manufacturing of clinical diagnostic kits for quantifying specific bile acid profiles in serum or urine.
• Biochemical Research: Employed in in vitro studies to explore receptor interactions (e.g., FXR, TGR5) and the role of sulfated bile acids in cellular signaling and inflammation.
• Toxicology Studies: Used to model and understand cholestasis and liver injury mechanisms, aiding in the safety assessment of new chemical entities.

Basic Information

Product Name	Glycochenodeoxycholic Acid 3-Sulfate Disodium Salt
CAS No.	66874-09-7
Molecular Formula	C₂₆H₄₁NNa₂O₉S
Molecular Weight	589.65 g/mol
Synonyms	Glycochenodeoxycholate 3-Sulfate Disodium Salt; 3-Sulfoglycochenodeoxycholic Acid Disodium Salt; Disodium Glycochenodeoxycholyltaurine 3-Sulfate; Sodium Glycochenodeoxycholate Sulfate; GCDCA-3S Disodium Salt; N-[(3α,5β,7α)-3,7-Dihydroxy-24-oxocholan-24-yl]glycine 3-(Hydrogen Sulfate) Disodium Salt; Taurochenodeoxycholic Acid 3-Sulfate Disodium Salt (common misnomer); Chenodeoxycholylglycine 3-Sulfate Disodium Salt
EINECS	Contact for details

Quality Control

Every batch of Glycochenodeoxycholic Acid 3-Sulfate Disodium Salt is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are suitable for use as pharmaceutical reference standards and in diagnostic applications. Comprehensive Certificates of Analysis (COA) detailing purity, impurities, and specific tests are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.