Description

n-Me-Ile-Oh·Hcl CAS NO 66866-68-0 is a protected amino acid derivative, specifically N-methylisoleucine hydrochloride, serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide structures and other bioactive molecules where stereochemistry is paramount. This high-purity intermediate is essential for research and development laboratories in the pharmaceutical, biotechnology, and agrochemical sectors, particularly for the synthesis of novel therapeutic peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the N-methylated isoleucine residue, enhancing metabolic stability and altering conformational properties.
• Biochemical Research: Employed in academic and industrial R&D for studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Agrochemical Development: Serves as a building block for synthesizing novel peptides with potential pesticidal or herbicidal activity.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new lead compounds.
• Protecting Group Strategy: The hydrochloride salt form offers improved handling and solubility characteristics for multi-step synthetic sequences.

Basic Information

Product Name	n-Me-Ile-Oh·Hcl
CAS No.	66866-68-0
Molecular Formula	C7H15NO2·HCl
Molecular Weight	181.66 g/mol (Free base: 145.20)
Synonyms	N-Methyl-L-isoleucine hydrochloride; (2S,3S)-2-(Methylamino)-3-methylpentanoic acid hydrochloride; L-N-Methylisoleucine HCl; N-Me-Ile-OH·HCl; Methylisoleucine hydrochloride; (S,S)-N-Methylisoleucine hydrochloride; 2-Methylamino-3-methylvaleric acid hydrochloride
EINECS	Contact for details

Quality Control

Our n-Me-Ile-Oh·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing specifications such as assay, enantiomeric excess, and impurity profiles are provided with every shipment. We support compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.