Description

3-Bromo-5-Methyl-1H-Pyrazolo[3,4-D]Pyrimidin-4(5H)-One is a high-purity heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile and critical intermediate for the development of novel pharmaceutical agents, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, drug discovery, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted therapeutic agents, especially protein kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Biochemical Tool Compound: Used in the development of probes and assay reagents for studying enzymatic pathways and cellular signaling.
• Agrochemical Research: Employed as a building block in the discovery of new active ingredients for crop protection.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under cGMP or research-grade conditions.
• Academic Research: Utilized in university and institutional labs for fundamental studies in heterocyclic chemistry and synthetic methodology.

Basic Information

Product Name	3-Bromo-5-Methyl-1H-Pyrazolo[3,4-D]Pyrimidin-4(5H)-One
CAS No.	66865-12-1
Molecular Formula	C6H5BrN4O
Molecular Weight	229.04 g/mol
Synonyms	3-Bromo-5-methyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one; 3-Bromo-5-methyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one; 4(5H)-Pyrazolo[3,4-d]pyrimidinone, 3-bromo-5-methyl-; 3-Bromo-5-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one; 66865-12-1; 3-Bromo-5-methyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one; 3-Bromo-5-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Methyl-1H-Pyrazolo[3,4-D]Pyrimidin-4(5H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with research and development specifications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.