Description

Enkephalin, Ala(2)-Pronh2(5)- is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified at the second and fifth amino acid positions. This compound is of significant interest for its role in neurobiological research, particularly in the study of opioid receptor binding, pain modulation pathways, and neurotransmitter function. It serves as a critical biochemical tool for pharmaceutical R&D, academic research institutions, and biotechnology companies focused on neuroscience, analgesic development, and peptide chemistry.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies investigating endogenous opioid systems, receptor-ligand interactions, and signal transduction mechanisms.
• Analgesic Drug Discovery: Serves as a key intermediate or pharmacological probe in the development of novel, non-addictive pain management therapeutics targeting opioid receptors.
• Biochemical Assays: Employed in competitive binding assays, enzyme-linked immunosorbent assays (ELISAs), and other in vitro tests to quantify receptor affinity and biological activity.
• Pharmacology Studies: Utilized in animal models to study the physiological effects, metabolism, and structure-activity relationships (SAR) of enkephalin analogs.
• Peptide Chemistry & Synthesis: Acts as a building block or template for the synthesis of more complex peptide derivatives and for method development in solid-phase peptide synthesis (SPPS).

Basic Information

Product Name	Enkephalin, Ala(2)-Pronh2(5)-
CAS No.	66864-07-1
Molecular Formula	C28H37N7O7
Molecular Weight	583.64 g/mol
Synonyms	[Ala2, Pro-NH25]-Enkephalin; H-Tyr-Ala-Gly-Phe-Pro-NH2; YAGFPR-NH2; Ala2-Pro5-enkephalinamide; (5-L-Prolinamide)-2-L-alanine-enkephalin; Opioid peptide analog 66864-07-1; Tyr-Ala-Gly-Phe-Pro-amide
EINECS	Contact for details

Quality Control

Our Enkephalin, Ala(2)-Pronh2(5)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.