Description

H-Phe-Gly-Oh Tfa is a protected dipeptide building block, specifically the trifluoroacetate salt of phenylalanylglycine. This high-purity intermediate is critical for the controlled synthesis of complex peptides and peptidomimetics in research and development. It is primarily utilized by pharmaceutical researchers, biotech companies, and fine chemical manufacturers engaged in peptide-based drug discovery and API production.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected fragment for the sequential assembly of longer peptide chains.
• Solution-Phase Peptide Synthesis: Used as a building block in classical coupling reactions for custom peptide manufacturing.
• Pharmaceutical Research: Serves as a crucial intermediate in the R&D of novel therapeutic peptides targeting various diseases.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, peptide hormones, and structural biology.
• Production of Peptidomimetics: Used to create modified peptide analogs with enhanced stability or biological activity.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening.

Basic Information

Product Name	H-Phe-Gly-Oh Tfa
CAS No.	66854-54-4
Molecular Formula	C13H15F3N2O5
Molecular Weight	336.27 g/mol
Synonyms	Phenylalanylglycine Trifluoroacetate Salt; H-Phe-Gly-OH x TFA; Fmoc-Phe-Gly-OH (precursor related); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanylglycine (related); L-Phenylalanyl-glycine TFA salt; Glycine, L-phenylalanyl-, trifluoroacetate (salt); (2S)-2-[[2-(2,2,2-Trifluoroacetyl)amino-1-oxoethyl]amino]-3-phenylpropanoic acid; Z-Phe-Gly-OH (related benzyloxycarbonyl protected variant)
EINECS	Contact for details

Quality Control

Our H-Phe-Gly-Oh Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with full batch traceability are provided to guarantee consistent quality and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -30° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.