Description

Val-Ala-Pro-Gly Acetate Salt is a high-purity synthetic peptide derivative, specifically the acetate salt form of the tetrapeptide sequence Val-Ala-Pro-Gly. This compound is of significant interest in advanced biochemical research and pharmaceutical development due to its role as a specific enzyme substrate or a key intermediate in peptide synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in proteomics, enzymology studies, and the development of novel therapeutic agents.

Application

• Enzymology Research: Used as a specific substrate for studying the activity and kinetics of proteolytic enzymes, particularly those targeting valine or alanine residues.
• Pharmaceutical Intermediates: Serves as a critical building block (GMP-grade available) in the solid-phase or solution-phase synthesis of larger, more complex therapeutic peptides.
• Biochemical Standards: Employed as a high-purity reference standard in analytical methods like HPLC and mass spectrometry for peptide quantification and identification.
• Protease Inhibitor Development: Acts as a core structure for designing and screening potential inhibitors for specific proteases involved in disease pathways.
• Cell Culture & Biomedical Studies: May be utilized in specialized cell culture media or as a component in studies of cell signaling and protein-protein interactions.

Basic Information

Product Name	Val-Ala-Pro-Gly Acetate Salt
CAS No.	66835-73-2
Molecular Formula	C18H30N4O6 • xC2H4O2
Molecular Weight	398.45 g/mol (Free base)
Synonyms	VAPG acetate salt; L-Valyl-L-alanyl-L-prolylglycine acetate; Tetrapeptide VAPG acetate; Val-Ala-Pro-Gly-OH • AcOH; H-Val-Ala-Pro-Gly-OH acetate; VAPG peptide acetate; N-Valyl-N-alanyl-N-prolylglycine acetate salt
EINECS	Contact for details

Quality Control

Our Val-Ala-Pro-Gly Acetate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing specifications for assay (by HPLC), related substances, residual solvents, acetate content, and other critical parameters. Our quality commitment supports applications requiring research-grade to cGMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For bulk quantities, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (IC)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.