Description

2-(4-Fluorophenyl)-1,3-dioxolane is a versatile fluorinated heterocyclic building block and protecting group reagent. This compound is valued for its role in synthetic organic chemistry, particularly in the development of pharmaceuticals and agrochemicals where the introduction of a fluorine atom is critical for modulating biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where fluorine substitution enhances efficacy and environmental persistence.
• Chemical Protecting Group: The 1,3-dioxolane moiety serves as a protecting group for carbonyl functionalities (aldehydes) in multi-step synthetic sequences.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals for electronic and optical applications.
• Academic & Industrial R&D: A valuable reagent for methodological development and exploratory chemistry in university and corporate laboratories.

Basic Information

Product Name	2-(4-Fluorophenyl)-1,3-dioxolane
CAS No.	66822-17-1
Molecular Formula	C9H9FO2
Molecular Weight	168.16 g/mol
Synonyms	4-Fluorobenzaldehyde ethylene acetal; 2-(4-Fluorophenyl)-1,3-dioxacyclopentane; 1,3-Dioxolane, 2-(4-fluorophenyl)-; p-Fluorobenzaldehyde ethylene acetal; 4-Fluorobenzaldehyde ethylenedioxy acetal; (4-Fluorophenyl)-1,3-dioxolane; Fluorobenzaldehyde ethylene acetal
EINECS	Contact for details

Quality Control

Our 2-(4-Fluorophenyl)-1,3-dioxolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.