Description

Pro-Opiomelanocortin (POMC) is a complex polypeptide prohormone that serves as a critical precursor for a range of biologically active neuropeptides and hormones. Its significance lies in its central role in the endocrine and nervous systems, where its cleavage products regulate vital processes including stress response, energy homeostasis, and pigmentation. This high-purity biochemical is essential for researchers in pharmaceutical development, neuroscience, and endocrinology, as well as for manufacturers of diagnostic reagents and advanced therapeutic peptides.

Application

• Biomedical Research: Fundamental studies on the biosynthesis and processing of ACTH, MSH, and endorphins.
• Drug Discovery & Development: Target identification and validation for disorders related to appetite, obesity, and stress.
• Diagnostic Reagent Production: Used as a reference standard or antigen in immunoassays to detect related hormones and peptides.
• Neuroscience Investigations: Research into the central melanocortin system and its role in behavior and physiology.
• Endocrine Studies: Exploration of adrenal gland function and the hypothalamic-pituitary-adrenal (HPA) axis.
• Peptide Synthesis & Standardization: Serves as a precursor model for the synthesis and quality control of derivative peptide fragments.

Basic Information

Product Name	Pro-Opiomelanocortin
CAS No.	66796-54-1
Molecular Formula	C~140H~230N~40O~44S (Approximate, varies by species and cleavage)
Molecular Weight	~30 kDa (Approximate, species-dependent)
Synonyms	POMC; Pro-opiomelanocortin; Corticotropin-lipotropin; Pro-ACTH/endorphin; Proopiomelanocortin; Adrenocorticotropin/β-lipotropin/β-endorphin precursor; NPP; Pro-γ-MSH
EINECS	Contact for details

Quality Control

Our Pro-Opiomelanocortin is produced and handled under stringent conditions to ensure batch-to-batch consistency and biological activity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, electrophoresis, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and bioactivity is provided with each shipment, supporting compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Protein Content (BCA)	≥ 90%
Biological Activity	Assessed by in-vitro assay (Contact for details)
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in aqueous buffers or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.