Description

Poly-o-Cbz-D-Tyrosine is a protected derivative of the non-natural D-enantiomer of the amino acid tyrosine, featuring a carboxybenzyl (Cbz) protecting group on the phenolic hydroxyl. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, where it provides precise stereochemical control and facilitates selective deprotection strategies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including antimicrobial peptides and hormone analogs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the solid-phase and solution-phase synthesis of bioactive peptides and peptidomimetic drugs.
• Antimicrobial Peptide Research: Used in the design and construction of D-amino acid containing peptides to enhance metabolic stability and biological activity.
• Hormone Analog Development: Employed in the synthesis of stabilized analogs of peptide hormones for research and therapeutic applications.
• Chemical Biology Probes: Acts as a building block for creating labeled or modified peptides used to study protein-protein interactions and enzyme mechanisms.
• Process Development: Utilized in scaling up synthetic routes for peptide-based Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Poly-o-Cbz-D-Tyrosine
CAS No.	66741-01-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	D-Tyrosine, N-[(benzyloxy)carbonyl]-, polymer; Poly[Nα-(benzyloxycarbonyl)-D-tyrosine]; Cbz-D-Tyrosine polymer; Poly(Cbz-D-Tyr); Poly(O-benzyloxycarbonyl-D-tyrosine); Poly(N-Carbobenzoxy-D-tyrosine); Poly(Nα-Cbz-D-tyrosine)
EINECS	Contact for details

Quality Control

Our Poly-o-Cbz-D-Tyrosine is produced and tested to meet the exacting standards required for pharmaceutical research and development. Each batch undergoes rigorous analytical characterization to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing key parameters such as chiral purity, degree of polymerization, and residual solvent content. We are committed to supply chain reliability and documentation transparency to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% D-isomer
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.