Description

Somatostatin, Ala(2)-Trp(8)-Cys(14)- is a synthetic, biologically active analog of the endogenous peptide hormone somatostatin, designed with specific amino acid substitutions to enhance its stability and receptor-binding profile. This compound is critical for advanced research in endocrinology and neurobiology, serving as a potent inhibitor of growth hormone, insulin, and glucagon secretion. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic disorders, oncology, and diagnostic applications.

Application

• Pharmaceutical Research & Development: As a reference standard and active ingredient in preclinical studies for novel therapeutics targeting somatostatin receptors (SSTRs).
• Endocrinology Studies: Investigation of hormonal regulation pathways, particularly the inhibition of growth hormone (GH), insulin, and glucagon release.
• Oncology Research: Exploration of anti-proliferative effects and potential use in the development of targeted cancer treatments, especially for neuroendocrine tumors.
• Metabolic Disorder Models: Used in experimental models for diabetes and acromegaly to study hormone modulation.
• Diagnostic Agent Development: Potential component in the development of radiopharmaceuticals and imaging agents for PET/CT scans.
• Biochemical & Cell Signaling Pathways: A key tool for studying G-protein coupled receptor (GPCR) signaling and intracellular transduction mechanisms.
• Peptide Chemistry & Analog Synthesis: Serves as a lead compound for the design and synthesis of new peptide analogs with improved pharmacokinetic properties.

Basic Information

Product Name	Somatostatin, Ala(2)-Trp(8)-Cys(14)-
CAS No.	66610-28-4
Molecular Formula	C76H104N18O19S2
Molecular Weight	1637.9 g/mol
Synonyms	Ala(2)-Trp(8)-Cys(14)-Somatostatin; Somatostatin (3-14), Ala(2)-Trp(8)-Cys(14)-; [Ala2, Trp8, Cys14]-Somatostatin; SRIF-14 analog; SMS 201-995 precursor analog; Cyclo(Ala-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys); H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (cyclic 3-14 disulfide)
EINECS	Contact for details

Quality Control

Our Somatostatin, Ala(2)-Trp(8)-Cys(14)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Amino Acid Composition	Conforms to theoretical values (±10%)
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.