Description

(D-Ala2,D-Leu5)-Enkephalin Amide is a synthetic peptide analog of the endogenous opioid peptide enkephalin, designed for enhanced metabolic stability and receptor selectivity. This compound is a critical research tool for studying opioid receptor pharmacology, pain pathways, and neurobiological signaling. It is primarily utilized by pharmaceutical R&D teams, academic neuroscience laboratories, and biochemical suppliers focused on neuropeptide research and drug discovery.

Application

• Neuroscience Research: Used as a selective ligand in receptor binding assays and functional studies to investigate δ-opioid receptor (DOR) activity and signaling mechanisms.
• Analytical Standard: Serves as a high-purity reference standard in HPLC, LC-MS, and other chromatographic methods for quality control and method validation.
• Biochemical Tool Compound: Employed in cell-based assays and in vitro studies to probe the physiological and pathological roles of the enkephalinergic system.
• Drug Discovery & Development: Acts as a key intermediate or pharmacophore model in the design and synthesis of novel analgesic and neuroprotective agents.
• Peptide Chemistry Studies: Utilized in research focusing on peptide stability, structure-activity relationships (SAR), and metabolic fate.

Basic Information

Product Name	(D-Ala2,D-Leu5)-Enkephalin Amide
CAS No.	66609-26-5
Molecular Formula	C28H46N6O7
Molecular Weight	578.71 g/mol
Synonyms	DADLE Amide; [D-Ala2, D-Leu5]-Enkephalin Amide; Tyr-D-Ala-Gly-Phe-D-Leu-NH2; H-Tyr-D-Ala-Gly-Phe-D-Leu-NH2; δ-opioid receptor agonist DADLE (amide form); (5R)-5-[[(2S)-2-[[2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-N-[[(1S)-1-benzyl-2-oxo-2-[[(2R)-1-oxopentan-2-yl]amino]ethyl]carbamoyl]pentanamide
EINECS	Contact for details

Quality Control

Every batch of our (D-Ala2,D-Leu5)-Enkephalin Amide is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. Certificates of Analysis (COA) detailing purity by HPLC, amino acid analysis, and mass spectrometry are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Purity (Titration)	≥ 97%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.