Description

H-Thr-Gly-Gly-Oh CAS NO 66592-75-4 is a synthetic tripeptide derivative composed of L-Threonine and two Glycine residues with a free C-terminal carboxylic acid. This compound serves as a crucial building block and intermediate in advanced pharmaceutical research and peptide synthesis. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers focused on creating novel therapeutic peptides, biochemical probes, and specialized biomaterials.

Application

• Pharmaceutical Intermediate: Key starting material or fragment in the solid-phase and solution-phase synthesis of complex therapeutic peptides.
• Biochemical Research: Used as a standard, substrate, or inhibitor in enzymatic studies and proteomics research to investigate peptide-protein interactions.
• Peptide Library Construction: An essential component for generating combinatorial peptide libraries for drug discovery and high-throughput screening.
• Conjugation Chemistry: The free carboxylic acid group enables conjugation to other molecules, carriers, or labels for creating targeted bioconjugates.
• Nutraceutical Development: Potential use in the research and development of bioactive peptide supplements and functional ingredients.
• Academic & Institutional Research: Serves as a model compound for studying peptide stability, folding, and degradation pathways.

Basic Information

Product Name	H-Thr-Gly-Gly-Oh
CAS No.	66592-75-4
Molecular Formula	C9H15N3O5
Molecular Weight	245.23 g/mol
Synonyms	L-Threonylglycylglycine; Thr-Gly-Gly; H-L-Thr-Gly-Gly-OH; Glycylglycine, L-threonyl-; Tripeptide (Thr-Gly-Gly); TGG; (2S,3R)-2-[(2-Aminoacetyl)amino]-3-hydroxybutanoylglycine; L-Thr-Gly-Gly
EINECS	Contact for details

Quality Control

Our H-Thr-Gly-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via mass spectrometry and IR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.