Description

(S)-(-)-Nicoumalone CAS NO 66556-78-3 is the single enantiomer of the anticoagulant compound nicoumalone, offering a high-purity standard for advanced pharmaceutical research and development. This specific stereoisomer is critical for studying structure-activity relationships and developing more targeted therapeutic agents with potentially improved efficacy and reduced side-effect profiles. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery, pharmacokinetic studies, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control testing of anticoagulant APIs and finished dosage forms.
• Drug Discovery & Development: Used as a key chiral intermediate or pharmacophore in the research and synthesis of new-generation vitamin K antagonist drugs and related therapeutic candidates.
• Metabolic and Pharmacokinetic Studies: Employed in in vitro and in vivo studies to investigate the metabolism, distribution, and enantioselective behavior of coumarin-based anticoagulants.
• Biochemical Research: Acts as a selective inhibitor in enzymatic assays to study the vitamin K epoxide reductase complex (VKOR) and related coagulation pathways.
• Analytical Method Development: Utilized to develop and calibrate sophisticated chiral separation techniques, such as chiral HPLC or capillary electrophoresis, for enantiomeric purity analysis.

Basic Information

Item	Detail
Product Name	(S)-(-)-Nicoumalone
CAS No.	66556-78-3
Molecular Formula	C19H15NO6
Molecular Weight	353.33 g/mol
Synonyms	(S)-Acenocoumarol; (S)-Acenocoumarin; (S)-3-(α-Acetonyl-4-nitrobenzyl)-4-hydroxycoumarin; (S)-Nicoumalone; (S)-(-)-Acenocoumarol; S-(-)-Acenocoumarol; (S)-4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one
EINECS	Contact for details

Quality Control

Every batch of our (S)-(-)-Nicoumalone is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and development purposes. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity, chemical purity (by HPLC), and identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.