Description

(R)-(+)-Nicoumalone is a high-purity, single-enantiomer chemical compound of significant interest in advanced pharmaceutical research and development. This optically active form is critical for studying stereospecific biological interactions and metabolic pathways. It serves as a key chiral intermediate or reference standard for scientists in medicinal chemistry and pharmacology, particularly for investigating anticoagulant mechanisms and developing targeted therapies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, GC) for quality control of active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Acts as a crucial chiral building block or precursor in the synthesis of novel, stereospecific drug candidates.
• Biochemical Studies: Employed in in vitro and in vivo studies to investigate the specific activity, metabolism, and pharmacokinetics of the (R)-enantiomer.
• Anticoagulant Mechanism Research: Serves as a tool compound for detailed studies on vitamin K antagonism and related coagulation pathways.
• Process Development & Optimization: Used in the development and validation of asymmetric synthesis routes and chiral separation techniques.

Basic Information

Product Name	(R)-(+)-Nicoumalone
CAS No.	66556-77-2
Molecular Formula	C19H15NO6
Molecular Weight	353.33 g/mol
Synonyms	(R)-(+)-Acenocoumarol; (R)-Acenocoumarol; (R)-3-(α-Acetonyl-4-nitrobenzyl)-4-hydroxycoumarin; (R)-4-Hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one; (R)-Nicoumalone; (R)-Sintrom; Dextrorotatory Nicoumalone; (R)-Enantiomer of Acenocoumarol
EINECS	Contact for details

Quality Control

Our (R)-(+)-Nicoumalone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is rigorously tested using advanced analytical techniques, including chiral HPLC, to confirm enantiomeric excess and identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and related substance analysis is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.