Description

4-tert-Butyl-2-Chloropyrimidine is a high-purity halogenated pyrimidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its reactive chloropyrimidine core, which enables efficient cross-coupling and nucleophilic substitution reactions for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport molecules and photoactive compounds.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP conditions.
• Academic & R&D Laboratories: Utilized in medicinal chemistry and synthetic methodology research for constructing diverse heterocyclic libraries.

Basic Information

Product Name	4-tert-Butyl-2-Chloropyrimidine
CAS No.	66522-06-3
Molecular Formula	C8H11ClN2
Molecular Weight	170.64 g/mol
Synonyms	2-Chloro-4-tert-butylpyrimidine; 4-(1,1-Dimethylethyl)-2-chloropyrimidine; 2-Chloro-4-(tert-butyl)pyrimidine; 4-tert-Butyl-2-chloropyrimidine; Pyrimidine, 2-chloro-4-(1,1-dimethylethyl)-; 2-Chloro-4-(1,1-dimethylethyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-tert-Butyl-2-Chloropyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to meet exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.