Description

Glycine, n-(Mercaptoacetyl)Glycylglycyl- is a specialized tripeptide derivative featuring a reactive mercaptoacetyl group, making it a valuable building block in advanced chemical synthesis. Its core value lies in its ability to introduce a thiol functionality into peptide chains, enabling site-specific conjugation, cross-linking, and the formation of stable disulfide bonds. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of targeted drug conjugates, diagnostic probes, and novel biomaterials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of targeted therapeutics, including antibody-drug conjugates (ADCs) and peptide-drug conjugates.
• Bioconjugation Chemistry: Used to introduce thiol groups onto peptides, proteins, or other biomolecules for site-specific labeling and functionalization.
• Research & Development: Serves as a critical reagent in medicinal chemistry for exploring new drug candidates and prodrug strategies.
• Diagnostic Agent Synthesis: Employed in the creation of contrast agents or labeled probes for molecular imaging and diagnostic assays.
• Biomaterial Engineering: Facilitates the cross-linking and modification of hydrogels or polymer scaffolds for tissue engineering applications.
• Chemical Biology Tool: Used to study protein-protein interactions and enzyme mechanisms through thiol-based probes.

Basic Information

Product Name	Glycine, n-(Mercaptoacetyl)Glycylglycyl-
CAS No.	66516-09-4
Molecular Formula	C8H13N3O5S
Molecular Weight	263.27 g/mol
Synonyms	N-(Mercaptoacetyl)glycylglycylglycine; Mercaptoacetyl-Gly-Gly-Gly-OH; MAG3 precursor; S-Acetyl-MAG3 deprotection intermediate; Gly-Gly-Gly-Mercaptoacetyl; Tripeptide thiol derivative; N-[(Mercaptoacetyl)amino]acetyl-glycylglycine; 2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetic acid, 2-mercapto-
EINECS	Contact for details

Quality Control

Our Glycine, n-(Mercaptoacetyl)Glycylglycyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and heavy metals. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation of the thiol group. The container should be kept in a cool, dry, and well-ventilated area, separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.