Description

S(+)-Baclofen CAS NO 66514-99-6 is the pharmacologically active enantiomer of the muscle relaxant Baclofen, offering superior potency and specificity for research and development. This high-purity chiral intermediate is critical for advancing targeted neurological therapies and studying GABAB receptor mechanisms. It is essential for pharmaceutical R&D laboratories, advanced fine chemical synthesis, and the development of next-generation central nervous system (CNS) agents.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control of Baclofen-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of enantiomerically pure Baclofen and its derivatives.
• Neurological Research: Used in preclinical studies to investigate the specific effects of the S-enantiomer on GABAB receptor signaling pathways.
• Methodology Development: Employed in chromatography (HPLC, GC) for developing and optimizing chiral separation techniques.
• Comparative Bioactivity Studies: Enables direct comparison of the pharmacological profile of S(+)-Baclofen against the racemic mixture or the R(-)-enantiomer.
• Regulatory Submissions: Provides essential data for drug master files (DMFs) and investigational new drug (IND) applications requiring enantiomeric characterization.

Basic Information

Product Name	S(+)-Baclofen
CAS No.	66514-99-6
Molecular Formula	C10H12ClNO2
Molecular Weight	213.66 g/mol
Synonyms	(S)-(+)-Baclofen; (3S)-4-Amino-3-(4-chlorophenyl)butanoic acid; L-Baclofen; (+)-Baclofen; (S)-Baclofen; β-(Aminomethyl)-4-chloro-benzenepropanoic acid (S)-; GABAB receptor agonist (S)-enantiomer
EINECS	Contact for details

Quality Control

Our S(+)-Baclofen is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.