Description

n-Methyl-n-(Trifluoromethylthio)Aniline is a specialized organofluorine and organosulfur compound featuring a unique trifluoromethylthio (-SCF₃) functional group. This structural motif is highly valued in modern chemical synthesis for its ability to dramatically influence the lipophilicity, metabolic stability, and binding affinity of target molecules. It serves as a critical advanced intermediate for researchers and manufacturers in the pharmaceutical and agrochemical sectors. Key industries that utilize this compound include pharmaceutical R&D for novel drug candidates and agrochemical production for next-generation crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the potent, metabolically stable trifluoromethylthio moiety to enhance drug-like properties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the -SCF₃ group contributes to improved biological activity and environmental profile.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials that benefit from its unique electronic and steric properties.
• Cross-Coupling Reactions: Serves as a reagent in palladium-catalyzed and other cross-coupling methodologies to introduce the -SCF₃ group into complex organic architectures.
• Fluorine Chemistry: An important substrate for further fluorination reactions and the study of fluorine-containing compounds in medicinal and synthetic chemistry.

Basic Information

Product Name	n-Methyl-n-(Trifluoromethylthio)Aniline
CAS No.	66476-44-6
Molecular Formula	C₈H₈F₃NS
Molecular Weight	207.22 g/mol
Synonyms	N-Methyl-N-[(trifluoromethyl)thio]aniline; N-Methyl-N-(trifluoromethylthio)benzenamine; Benzenamine, N-methyl-N-[(trifluoromethyl)thio]-; N-(Trifluoromethylthio)-N-methylaniline; Methyl(trifluoromethylthio)phenylamine; N-Phenyl-N-methyltrifluoromethanesulfenamide
EINECS	Contact for details

Quality Control

Our n-Methyl-n-(Trifluoromethylthio)Aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to confirm identity and quantify purity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with global regulatory frameworks, and custom synthesis to meet specific purity or packaging requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.