Description

H-D-Glu(Trp-Oh)-Oh is a protected dipeptide derivative, specifically the H-D-Glutamic acid α-benzyl ester coupled with Tryptophan. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic probes, and biochemical tools.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the solid-phase and solution-phase synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in academic and industrial R&D for constructing model peptides to study protein folding, enzyme-substrate interactions, and receptor binding.
• Peptidomimetic Development: Acts as a foundational component for creating non-natural peptide analogs with enhanced metabolic stability and bioavailability.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Neuroscience Research: Potential use in synthesizing neuropeptide analogs for studying neurological pathways and disorders.

Basic Information

Product Name	H-D-Glu(Trp-Oh)-Oh
CAS No.	66471-20-3
Molecular Formula	C₂₅H₂₇N₃O₆
Molecular Weight	465.50 g/mol
Synonyms	H-D-Glu(OBzl)-Trp-OH; H-D-Glutamic acid α-benzyl ester tryptophan; D-Glu(OBzl)-Trp; N-[(Benzyloxy)carbonyl]-D-glutamyltryptophan; (2R)-2-[[(2S)-2-Amino-4-(benzyloxy)-4-oxobutanoyl]amino]-3-(1H-indol-3-yl)propanoic acid; Z-D-Glu(OBzl)-Trp-OH; Fmoc-D-Glu(OBzl)-Trp-OH (when using Fmoc protection); Protected D-Glutamyl-Tryptophan dipeptide
EINECS	Contact for details

Quality Control

Our H-D-Glu(Trp-Oh)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.