Description

Benzenamine, 2,5-Bis(2,2,2-Trifluoroethoxy)- is a specialized fluorinated aniline derivative, identified by CAS number 66300-37-6. This compound is a high-value intermediate prized for its unique combination of an aromatic amine core and trifluoroethoxy substituents, which impart significant electronic and steric properties. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and advanced materials sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug molecules, particularly those requiring fluorinated motifs to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic displays and organic light-emitting diodes (OLEDs), influencing charge transport and emission properties.
• Polymer Modification: Employed to introduce fluorinated aniline units into polymer backbones, creating materials with enhanced chemical resistance, thermal stability, and unique surface characteristics.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to create novel ligands for catalysis, leveraging the electron-withdrawing trifluoroethoxy groups to fine-tune metal center reactivity.
• Advanced Material Research: Acts as a critical monomer or cross-linking agent in the development of specialty coatings, adhesives, and high-performance resins.

Basic Information

Product Name	Benzenamine, 2,5-Bis(2,2,2-Trifluoroethoxy)-
CAS No.	66300-37-6
Molecular Formula	C₁₀H₉F₆NO₂
Molecular Weight	289.18 g/mol
Synonyms	2,5-Bis(2,2,2-trifluoroethoxy)aniline; 2,5-Bis(2,2,2-trifluoroethoxy)benzenamine; 1-Amino-2,5-bis(2,2,2-trifluoroethoxy)benzene; 2,5-Bis(trifluoroethoxy)aniline; Aniline, 2,5-bis(2,2,2-trifluoroethoxy)-; 2,5-Di(2,2,2-trifluoroethoxy)aniline
EINECS	Contact for details

Quality Control

Every batch of Benzenamine, 2,5-Bis(2,2,2-Trifluoroethoxy)- is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specification parameters is provided with each shipment to guarantee traceability and support your regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.