Description

Aspartyl-Alanyl-Histidine-n-Methylamide CAS NO 66277-14-3 is a synthetic tripeptide derivative, specifically an N-methylated analog of the Asp-Ala-His sequence. This compound is of significant interest in advanced biochemical research and pharmaceutical development due to its modified peptide backbone, which can influence stability, receptor binding, and metabolic pathways. It serves as a critical building block and reference standard for researchers in medicinal chemistry, peptide synthesis, and metabolic studies, addressing the need for high-purity, well-characterized specialty biochemicals.

Application

• Pharmaceutical Research & Development: Used as a key intermediate or reference standard in the synthesis and study of novel peptide-based therapeutics and drug candidates.
• Medicinal Chemistry: Serves as a model compound for investigating structure-activity relationships (SAR), peptide methylation effects, and bioavailability optimization.
• Biochemical Research: Employed in enzymatic studies, metabolic pathway analysis, and as a substrate or inhibitor in protease and peptidase assays.
• Cosmeceutical Development: Investigated for potential applications in advanced skincare formulations targeting specific biological pathways.
• Academic & Institutional Research: Provides a high-purity chemical tool for universities and research institutes studying peptide chemistry and biochemistry.
• Process Development & Scale-up: Acts as a benchmark for developing and optimizing synthetic routes for complex peptide derivatives in pilot and commercial production.

Basic Information

Product Name	Aspartyl-Alanyl-Histidine-n-Methylamide
CAS No.	66277-14-3
Molecular Formula	C17H26N7O6
Molecular Weight	424.44 g/mol
Synonyms	Asp-Ala-His-NHMe; N-Methyl-Aspartyl-Alanyl-Histidinamide; L-Aspartyl-L-alanyl-L-histidine N-methylamide; Aspartylalanylhistidine N-methylamide; DAH-NHMe; H-Asp-Ala-His-NH-CH3; Tripeptide derivative Asp-Ala-His methylamide; N-Methylated Asp-Ala-His
EINECS	Contact for details

Quality Control

Every batch of Aspartyl-Alanyl-Histidine-n-Methylamide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (HPLC), chiral purity, and related substances. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.