Description

Pth-α-Methyl-Dl-Serine is a protected amino acid derivative, specifically an N-phthaloyl-α-methylserine, serving as a crucial chiral building block in advanced organic synthesis. This compound is valued for its role in introducing the α-methylserine moiety into peptide chains and complex molecules, enabling the study of structure-activity relationships and the development of novel bioactive compounds. It is primarily sought by research institutions and pharmaceutical companies engaged in peptide mimetic design, medicinal chemistry, and the synthesis of specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel peptide-based drugs and enzyme inhibitors.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate the non-proteinogenic amino acid α-methylserine, modifying peptide stability and bioactivity.
• Medicinal Chemistry Research: Serves as a building block for creating compound libraries to explore new therapeutic targets, particularly in metabolic and neurological disorders.
• Bioconjugation: Potential use in linker chemistry for antibody-drug conjugates (ADCs) or prodrug development due to its protected functional groups.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged molecules for studying biological pathways and protein interactions.
• Fine Chemical Synthesis: An intermediate in the multi-step synthesis of complex natural products or specialty chemicals requiring specific stereochemistry.

Basic Information

Product Name	Pth-α-Methyl-Dl-Serine
CAS No.	66256-33-5
Molecular Formula	C12H11NO5
Molecular Weight	249.22 g/mol
Synonyms	N-Phthaloyl-α-methyl-DL-serine; (±)-N-Phthaloyl-α-methylserine; DL-α-Methylserine N-phthalimide; Phthalimidomethylserine; 2-Phthalimido-2-methyl-3-hydroxypropanoic acid; 2-Methyl-2-(1,3-dioxoisoindolin-2-yl)-3-hydroxypropanoic acid; PTH-α-Me-Ser-OH
EINECS	Contact for details

Quality Control

Our Pth-α-Methyl-Dl-Serine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.