Description

4-(Trifluoromethoxy)Benzaldehyde is a high-purity aromatic aldehyde building block characterized by its trifluoromethoxy substituent, which imparts unique electronic and steric properties. This compound is essential for introducing the 4-(trifluoromethoxy)benzyl moiety into target molecules, significantly enhancing their lipophilicity, metabolic stability, and binding affinity. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, where precise molecular modification is required for advanced product development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) drugs, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorine-containing liquid crystal compounds used in high-performance displays.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Functional Dyes and Pigments: Intermediate for synthesizing specialized dyes with enhanced light-fastness and chemical resistance.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed reactions like Suzuki-Miyaura coupling for creating complex biaryl structures.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	4-(Trifluoromethoxy)Benzaldehyde
CAS No.	65902-80-9
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	p-(Trifluoromethoxy)benzaldehyde; 4-(Trifluoromethoxy)benzaldehyde; α,α,α-Trifluoro-p-anisaldehyde; Benzaldehyde, 4-(trifluoromethoxy)-; 1-Trifluoromethoxy-4-formylbenzene; 4-Formylphenyl trifluoromethyl ether; Trifluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.