Description

Caerulein, Nle(8)- is a synthetic analog of the natural peptide hormone caerulein, characterized by the substitution of norleucine at position 8. This modification enhances its stability and bioactivity, making it a valuable research-grade biochemical for pharmacological and physiological studies. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors investigating gastrointestinal and central nervous system functions.

Application

• Pharmacological Research: Used as a potent cholecystokinin (CCK) receptor agonist to study receptor binding, signal transduction, and the physiological effects of CCK.
• Gastrointestinal Studies: Employed in experimental models to investigate pancreatic secretion, gallbladder contraction, and gut motility.
• Neuroscience Research: Applied in studies exploring the role of CCK in satiety, anxiety, analgesia, and dopamine-mediated behaviors in the central nervous system.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel therapeutics targeting CCK receptors for metabolic and neurological disorders.
• Biochemical Assays: Used as a high-purity reagent in enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIAs), and other in vitro diagnostic test development.

Basic Information

Product Name	Caerulein, Nle(8)-
CAS No.	65864-30-4
Molecular Formula	C58H73N13O21S2
Molecular Weight	1352.4 g/mol
Synonyms	Norleucine(8)-Caerulein; Nle(8)-Caerulein; Caerulein (8-Nle); Ceruletide (8-Nle); pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Nle-Asp-Phe-NH2; L-Glutamine, N-(N-(N-(N-(N-(N-(1-deoxy-1-((1-oxo-2-((1-oxo-3-phenylpropyl)amino)ethyl)amino)-D-glucitol-2-yl)-L-tryptophyl)-L-norleucyl)-L-α-aspartyl)-L-tyrosyl-O-sulfate)-L-threonyl)-, 1→5-lactone; (8-Norleucine)-caerulein
EINECS	Contact for details

Quality Control

Our Caerulein, Nle(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content (Amino Acid Analysis)	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.