Description

(D-Ser6)-Goserelin is a synthetic peptide analog of gonadotropin-releasing hormone (GnRH) with a D-serine substitution at position 6. This modification confers enhanced metabolic stability and a specific pharmacological profile, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical companies and research institutions focused on developing novel therapeutics in oncology and endocrinology, particularly for hormone-dependent conditions.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of Goserelin acetate, a potent GnRH agonist used in cancer therapy.
• Research & Development: Used in preclinical studies to investigate structure-activity relationships (SAR) of GnRH analogs.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in peptide manufacturing.
• Peptide Chemistry Studies: Employed in academic and industrial research to study the effects of D-amino acid substitutions on peptide stability and receptor binding.
• Process Development: Used for scaling up and optimizing synthetic routes for complex peptide APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	(D-Ser6)-Goserelin
CAS No.	65807-03-6
Molecular Formula	C59H84N18O14
Molecular Weight	1269.4 g/mol
Synonyms	Goserelin (D-Ser6) analog; D-Ser(6)-Goserelin; [D-Ser6]-Goserelin; (D-Serine6)-Goserelin; GnRH agonist analog (D-Ser6); LHRH analog (D-Ser6); AY-25650 (D-Ser6) analog; Zoladex intermediate (D-Ser6)
EINECS	Contact for details

Quality Control

Our (D-Ser6)-Goserelin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to verify the D-serine configuration. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and cGMP-grade standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Chiral Purity (D-Ser)	≥ 99.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.