Description

H-D-Phg-Otbu Hcl CAS NO 65715-93-7 is a protected amino acid derivative, specifically the hydrochloride salt of N-(tert-Butoxycarbonyl)-D-phenylglycine. This high-purity chiral building block is essential for the synthesis of complex peptides and active pharmaceutical ingredients (APIs) where stereochemical integrity is critical. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs, antibiotics, and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce the D-phenylglycine residue with a protected α-amino group.
• API Development: Serves as a critical building block in the research and scale-up production of new active pharmaceutical ingredients requiring specific stereochemistry.
• Bioconjugation: Employed in the preparation of modified peptides and peptide-drug conjugates for targeted therapies.
• Chemical Biology Research: Utilized as a tool compound in studying enzyme mechanisms and protein-protein interactions.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in the preparation of other non-natural amino acids and chiral catalysts.

Basic Information

Product Name	H-D-Phg-Otbu Hcl
CAS No.	65715-93-7
Molecular Formula	C₁₃H₁₈ClNO₄
Molecular Weight	287.74 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-phenylglycine hydrochloride; Boc-D-Phg-OH·HCl; (R)-2-((tert-Butoxycarbonyl)amino)-2-phenylacetic acid hydrochloride; Boc-D-α-phenylglycine HCl; D-Boc-phenylglycine hydrochloride; (R)-Boc-amino(phenyl)acetic acid HCl; N-Boc-D-phenylglycine hydrochloride; Boc-D-Phenylglycine HCl
EINECS	Contact for details

Quality Control

Our H-D-Phg-Otbu Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.