Description

2,2,2-Trifluoro-1-(4-Methoxy-Phenyl)-Ethylamine Hydrochloride is a high-purity, fluorinated aromatic amine hydrochloride salt of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate a trifluoroethylamine moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Intermediate for synthesizing fluorinated polymers and advanced organic materials with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring fluorinated amine chemistry.
• Academic & Industrial R&D: Employed in research laboratories for methodological studies in fluorination chemistry and the exploration of new synthetic pathways.

Basic Information

Product Name	2,2,2-Trifluoro-1-(4-Methoxy-Phenyl)-Ethylamine Hydrochloride
CAS No.	65686-77-3
Molecular Formula	C9H11ClF3NO
Molecular Weight	241.64 g/mol
Synonyms	1-(4-Methoxyphenyl)-2,2,2-trifluoroethanamine Hydrochloride; (R/S)-1-(4-Methoxyphenyl)-2,2,2-trifluoroethylamine HCl; α-(Trifluoromethyl)-4-methoxybenzylamine Hydrochloride; 4-Methoxy-α-(trifluoromethyl)benzylamine Hydrochloride; 2,2,2-Trifluoro-1-(4-methoxyphenyl)ethan-1-amine Hydrochloride; 1-(4-Methoxyphenyl)-2,2,2-trifluoroethylamine Hydrochloride; 4-Methoxy-α-(trifluoromethyl)benzenemethanamine Hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(4-Methoxy-Phenyl)-Ethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory standards (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.