Description

Z-D-Leu-Osu is a high-purity, protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over stereochemistry and side-chain functionality during solid-phase or solution-phase peptide assembly. It is particularly valuable for the pharmaceutical, biotechnology, and life science research industries, enabling the development of novel therapeutic peptides and biochemical probes.

Application

• Peptide Synthesis: A crucial reagent for the controlled incorporation of D-leucine into custom peptide sequences.
• Pharmaceutical Intermediates: Serves as a key chiral intermediate in the research and development of active pharmaceutical ingredients (APIs).
• Bioconjugation: Used to modify proteins, antibodies, or other biomolecules by introducing leucine residues with specific protecting groups.
• Proteomics Research: Employed in the synthesis of peptide standards, enzyme substrates, or inhibitors for biochemical assays.
• Combinatorial Chemistry: A valuable building block for generating diverse chemical libraries for drug discovery screening.
• Academic & Industrial R&D: Supports fundamental research in medicinal chemistry, structural biology, and chemical biology.

Basic Information

Product Name	Z-D-Leu-Osu
CAS No.	65581-25-1
Molecular Formula	C17H22N2O6
Molecular Weight	350.37 g/mol
Synonyms	N-Carbobenzoxy-D-leucine N-hydroxysuccinimide ester; Z-D-Leucine N-succinimidyl ester; Z-D-Leu-OSu; N-(Benzyloxycarbonyl)-D-leucine N-succinimidyl ester; D-Leucine, N-[(phenylmethoxy)carbonyl]-, 1,2,3,6-tetrahydro-2,5-dioxo-3-furanylester; N-Cbz-D-leucine N-hydroxysuccinimide ester; Cbz-D-Leu-OSu; Benzyloxycarbonyl-D-leucine N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Z-D-Leu-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and loss on drying. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Loss on Drying	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.