Description

3'-Deoxykanamycin C is a semi-synthetic derivative of the aminoglycoside antibiotic kanamycin, characterized by the removal of the hydroxyl group at the 3' position of its glucosamine ring. This structural modification is significant for research into the structure-activity relationships of aminoglycosides and their interactions with bacterial ribosomes. It serves as a critical pharmaceutical reference standard and research chemical for scientists in antimicrobial development, molecular biology, and medicinal chemistry.

Application

• Pharmaceutical Research & Development: Used as a key intermediate or reference standard in the synthesis and study of novel aminoglycoside antibiotics.
• Microbiological Studies: Employed in research to investigate bacterial resistance mechanisms, particularly those involving enzymatic modification of aminoglycosides.
• Biochemical Research: Serves as a tool compound for studying ribosomal RNA binding and protein synthesis inhibition.
• Analytical Standard: Essential for the quality control and HPLC/LC-MS analysis of kanamycin-related compounds in pharmaceutical preparations.
• Medicinal Chemistry: Provides a core scaffold for the design and development of new antimicrobial agents with potentially improved efficacy and reduced toxicity.

Basic Information

Product Name	3'-Deoxykanamycin C
CAS No.	65566-75-8
Molecular Formula	C18H36N4O10
Molecular Weight	468.50 g/mol
Synonyms	3'-Deoxykanamycin C; Kanamycin 3'-Deoxy Derivative; 6-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-4-O-(6-amino-6-deoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine; 3'-Deoxykanamycin; Antibiotic NK 1003; NK-1003
EINECS	Contact for details

Quality Control

Every batch of 3'-Deoxykanamycin C is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting compliance with in-house specifications. Our quality commitment supports reliable and reproducible results in your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.