Description

Somatostatin, Des-Ala(1)- is a synthetic analog of the endogenous peptide hormone somatostatin, characterized by the removal of the N-terminal alanine residue. This modification can enhance metabolic stability and receptor selectivity, making it a valuable tool for advanced biochemical and pharmacological research. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on endocrinology, neurobiology, and the development of novel therapeutic agents targeting somatostatin receptor pathways.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of somatostatin receptor (SSTR) binding, signaling, and internalization mechanisms.
• Pharmacological Development: Serves as a key intermediate or lead compound in the design and screening of new peptide-based therapeutics for endocrine disorders and cancers.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays (e.g., ELISA, RIA) for the detection and quantification of somatostatin and related peptides.
• Cell Biology Studies: Applied in cell culture experiments to investigate the inhibitory effects on hormone secretion (e.g., growth hormone, insulin, glucagon).
• Neuroscience Research: Utilized to study the neuromodulatory roles of somatostatin in the central and peripheral nervous systems.
• Stability & Metabolism Studies: Acts as a model compound for investigating peptide degradation pathways and optimizing formulation strategies for enhanced stability.

Basic Information

Product Name	Somatostatin, Des-Ala(1)-
CAS No.	65330-61-2
Molecular Formula	C75H104N18O19S2
Molecular Weight	1633.9 g/mol
Synonyms	Des-Ala1-Somatostatin; Des-Alanine1-Somatostatin; Somatostatin (1-14), Des-Ala1-; [Des-Ala1]-Somatostatin; SRIF (1-14), Des-Ala1-; Growth Hormone Release-Inhibiting Hormone (1-14), Des-Ala1-; Ala1-Deleted Somatostatin; H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (cyclic 3-14 disulfide)
EINECS	Contact for details

Quality Control

Our Somatostatin, Des-Ala(1)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. We provide comprehensive Certificates of Analysis (COA) detailing all specifications to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.