Description

15-Des-Trp-Phe-Gramicidin A is a defined analog of the natural ionophore antibiotic gramicidin A, specifically engineered by the removal of tryptophan and phenylalanine residues. This modification is significant for researchers studying the structure-activity relationships of channel-forming peptides and their interaction with lipid bilayers. It is primarily needed by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on membrane biophysics, antimicrobial mechanisms, and novel drug delivery systems.

Application

• Membrane Biophysics Research: As a model compound for studying the formation and properties of ion channels in artificial and biological membranes.
• Antimicrobial Mechanism Studies: Used to investigate the fundamental principles of ionophore activity and bacterial membrane disruption.
• Structure-Activity Relationship (SAR) Analysis: Critical for understanding how specific amino acid sequences in gramicidin analogs influence channel conductance, selectivity, and stability.
• Drug Discovery Screening: Serves as a reference standard or tool compound in assays designed to discover new antibiotics or modulators of membrane function.
• Academic & Educational Use: Employed in advanced biochemistry and biophysics laboratories for teaching principles of peptide-lipid interactions.

Basic Information

Product Name	15-Des-Trp-Phe-Gramicidin A
CAS No.	65284-03-9
Molecular Formula	C86H124N18O17
Molecular Weight	1681.99 g/mol
Synonyms	Gramicidin A, 15-Des-Trp-Phe-; [Val1,Ala3,Leu5,Ala7,Leu9,Ala11,Leu13,Leu15]Gramicidin A; Des-Trp-Phe-Gramicidin A; Gramicidin A Analog; Ionophore Peptide Analog; Channel-Forming Peptide Derivative; Linear Gramicidin Analog
EINECS	Contact for details

Quality Control

Our 15-Des-Trp-Phe-Gramicidin A is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for reproducible research results. Each lot undergoes comprehensive analytical characterization including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.