Description

n-ε-Lithocholyllysine is a chemically modified bile acid derivative where lithocholic acid is conjugated to the ε-amino group of lysine. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a key intermediate or reference standard in the study of bile acid metabolism, receptor interactions, and drug delivery systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on hepatology, gastroenterology, and metabolic disorders.

Application

• Biochemical Research Standard: Serves as a critical reference compound for analytical method development and validation in studies of bile acid conjugation and transport.
• Pharmaceutical Intermediate: Used in the synthesis of more complex bile acid-based drug candidates targeting nuclear receptors like FXR (Farnesoid X Receptor).
• Metabolic Pathway Studies: Employed in in vitro and in vivo research to investigate the role of conjugated bile acids in liver function and intestinal absorption.
• Diagnostic Reagent Development: Acts as a calibrant or antigen in the development of immunoassays for detecting specific bile acid profiles in clinical samples.
• Prodrug Synthesis: Utilized as a building block for creating prodrugs where therapeutic agents are linked via the lysine moiety for targeted delivery to the liver or intestines.
• Cell Culture & Toxicology: Applied in cell-based assays to study bile acid cytotoxicity, cell signaling, and the effects of bile acid derivatives on cell membranes.

Basic Information

Product Name	n-ε-Lithocholyllysine
CAS No.	65236-49-9
Molecular Formula	C30H50N2O5
Molecular Weight	518.73 g/mol
Synonyms	Nε-Lithocholyl-L-lysine; Lithocholyllysine; L-Lysine, N6-(3α-hydroxy-5β-cholan-24-oyl)-; N6-(3α-Hydroxy-5β-cholan-24-oyl)-L-lysine; (3α,5β)-3-Hydroxy-N6-[2-[[(1S)-1-carboxy-4-aminobutyl]amino]-2-oxoethyl]cholan-24-amide; Lithocholic acid-lysine conjugate; Bile acid-lysine amide
EINECS	Contact for details

Quality Control

Our n-ε-Lithocholyllysine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications such as assay, impurity profile, and physical characteristics. We adhere to ISO 9001 quality management principles, and our processes are designed to meet the exacting standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.