Description

2-Chloro-6-Methyl-5-Nitro-4(1H)-Pyrimidinone is a versatile halogenated and nitrated pyrimidinone derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both chloro and nitro substituents, makes it a valuable electrophile and building block for constructing complex heterocyclic systems. This compound is primarily sought after by research institutions and pharmaceutical development companies for the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty dyes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other small molecule drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators due to its bioactive pyrimidine core.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitution, and as a scaffold for constructing fused heterocycles.
• Dye and Pigment Manufacturing: Acts as an intermediate for creating specialized azo dyes and colorants with specific light-fastness properties.
• Material Science Research: Investigated for the development of organic electronic materials and metal-organic frameworks (MOFs).
• Biochemical Tool Compound: Utilized in biochemical assays and as a standard for analytical method development in quality control laboratories.

Basic Information

Product Name	2-Chloro-6-Methyl-5-Nitro-4(1H)-Pyrimidinone
CAS No.	65224-66-0
Molecular Formula	C5H4ClN3O3
Molecular Weight	189.56 g/mol
Synonyms	5-Nitro-2-chloro-6-methyl-4(1H)-pyrimidinone; 2-Chloro-6-methyl-5-nitropyrimidin-4-ol; 4-Hydroxy-2-chloro-6-methyl-5-nitropyrimidine; 5-Nitro-2-chloro-6-methyl-4-pyrimidinol; 2-Chloro-6-methyl-5-nitro-1H-pyrimidin-4-one; 65224-66-0; 2-Chloro-6-methyl-5-nitropyrimidin-4(1H)-one
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Methyl-5-Nitro-4(1H)-Pyrimidinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.