Description

Pyroglutamylhistidyl-n-Ethylamide CAS NO 65213-42-5 is a synthetic peptide derivative of significant interest in advanced biochemical research and development. This compound serves as a key intermediate and building block for the synthesis of more complex peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuropeptide studies, cosmetic ingredient innovation, and the development of novel bioactive molecules.

Application

• Biochemical Research: As a reference standard and intermediate in neuropeptide and signal transduction studies.
• Cosmetic & Skincare Actives: Investigation as a potential precursor for anti-aging or skin-conditioning peptide ingredients.
• Pharmaceutical Development: Serving as a building block for novel drug candidates, particularly in neurological and metabolic disorders.
• Peptide Synthesis: A specialized raw material for solid-phase or solution-phase peptide synthesis.
• Enzyme Substrate Studies: Used in research to study enzyme kinetics and specificity of proteases and peptidases.
• Academic Research: Fundamental studies in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	Pyroglutamylhistidyl-n-Ethylamide
CAS No.	65213-42-5
Molecular Formula	C13H21N5O3
Molecular Weight	295.34 g/mol
Synonyms	Pyroglutamyl-histidyl-ethylamide; pGlu-His-NHEt; L-Pyroglutamyl-L-histidyl ethylamide; 5-Oxo-L-prolyl-L-histidyl ethylamide; Ethylamide, Pyroglutamylhistidyl-; TRH (Thyrotropin-Releasing Hormone) analog fragment; pGlu-His-EtNH2
EINECS	Contact for details

Quality Control

Our Pyroglutamylhistidyl-n-Ethylamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. We provide full traceability and a detailed Certificate of Analysis (COA) with every shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.