Description

Enkephalinamide-Leu, Ala(2)- CAS NO 65189-64-2 is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified at the C-terminus. This compound is of significant interest for its potential role in neurobiological research and pharmaceutical development, particularly in the study of opioid receptor interactions and pain modulation pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, peptide chemistry, and analgesic drug discovery.

Application

• Neuroscience Research: Used as a reference standard or active agent in studies investigating the endogenous opioid system, receptor binding affinity, and signal transduction mechanisms.
• Pharmacological Studies: Employed in in vitro and in vivo assays to evaluate analgesic properties, tolerance development, and side-effect profiles of opioid-like compounds.
• Biochemical Tool: Serves as a substrate or inhibitor in enzymatic studies related to peptide metabolism and degradation pathways.
• Drug Discovery: Acts as a key intermediate or lead compound in the design and synthesis of novel peptide-based therapeutics targeting pain management.
• Analytical Reference: Provides a high-purity standard for method development and validation in analytical techniques such as HPLC and mass spectrometry within quality control laboratories.

Basic Information

Product Name	Enkephalinamide-Leu, Ala(2)-
CAS No.	65189-64-2
Molecular Formula	C28H38N6O7
Molecular Weight	570.64 g/mol
Synonyms	H-Tyr-Gly-Gly-Phe-Leu-NH2 (modified); [Leu5]-Enkephalinamide; Leu-Enkephalinamide; L-Leucine-enkephalinamide; Tyr-Gly-Gly-Phe-Leu-NH2; Opioid peptide analog; (5-L-Leucine)enkephalinamide; N-(N-(N-(N2-(N-L-Tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)glycinamide
EINECS	Contact for details

Quality Control

Our Enkephalinamide-Leu, Ala(2)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to a quality management system to support our commitment to reliable supply for the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.