Description

2-D-Alanine-β-Endorphin is a synthetic peptide analog of the endogenous opioid neuropeptide β-endorphin. This compound is significant for research into pain modulation, stress response, and neuropsychiatric disorders due to its interaction with opioid receptors. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience and analgesic drug discovery.

Application

• Neuroscience Research: Used as a reference standard or active agent in studies investigating endogenous opioid systems, receptor binding affinity, and signal transduction pathways.
• Analgesic Drug Development: Serves as a key intermediate or pharmacological tool in the discovery and screening of novel pain management therapeutics.
• Biochemical Assays: Employed in competitive binding assays, ELISA development, and other in vitro tests to study opioid receptor function and ligand interactions.
• Pharmacology Studies: Utilized in animal models to evaluate the physiological and behavioral effects of opioid peptide analogs on pain perception and stress responses.
• Peptide Chemistry Reference: Acts as a standard for analytical method development, such as HPLC or LC-MS, for peptide purity and identity confirmation.

Basic Information

Product Name	2-D-Alanine-β-Endorphin
CAS No.	65041-91-0
Molecular Formula	C149H240N42O45S
Molecular Weight	~3350.8 g/mol
Synonyms	[D-Ala2]-β-Endorphin; β-Endorphin (2-D-alanine); H-Tyr-D-Ala-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH; D-Ala2 β-Endorphin Human; β-Endorphin, 2-D-alanine-
EINECS	Contact for details

Quality Control

Our 2-D-Alanine-β-Endorphin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPIC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.